The paper is in principle accepted after revision based on the reviewer’s comments. Authors are given five days for minor revisions.

The acceptance of the manuscript would depend on the revisions. The author needs to provide a point by point response or provide a rebuttal if some of the reviewer’s comments cannot be revised. Usually, a maximum of two rounds of major revision per manuscript is normally provided. Authors will be asked to resubmit the revised paper within a suitable time frame, and the revised version will be returned to the reviewer for further comments. If the required revision time is estimated to be longer than 2 months, we will recommend that authors withdraw their manuscript before resubmitting so as to avoid unnecessary time pressure and to ensure that all manuscripts are sufficiently revised.

• If additional experiments are needed to support the conclusions, the manuscript will be rejected and the authors will be encouraged to re-submit the paper once further experiments have been conducted.

• The article has serious flaws, and/or makes no original significant contribution. No offer of resubmission is provided.